Mesenchymal Stem Cells: Intrinsic/Extrinsic Factors Regulating Stemness, Growth, and Differentiation Mesenchymal stem/stromal cells (MSCs) are adult stem cells with the capability of self-renewal and multilineage differentiation into skeletal and/or mesodermal tissues, including bone, fat, cartilage, and [...]
Crosstalk between Inflammation and Carcinogenesis Inflammation is a significant factor to be considered alongside altered innate immune responses and chronic inflammation as triggering events for the oncogenic mechanism, which leads to the cell transformation and tumor.The multistep carcinogenesis [...]
Non-Coding DNA in Human Health and Diseases Coding DNA represents approximately 2% of the human genome, as well as of the genomes of other eukaryotic organisms. One of the most puzzling biological questions is understanding the [...]
Biochemical and Cellular Mechanisms Regulating ER-to-Golgi Vesicular Trafficking in Health and Disease Secretory proteins and membranes exit the ER into ER-derived carriers and transported to the Golgi before being sorted and delivered to their final destination. [...]
Extracellular Vesicles as Modulators of Cancer Cell Adaptive Responses Linked to Therapy Resistance Despite the massive efforts of biomedical scientists worldwide, cancer still ranks as the leading cause of death, with approximately 20 million new cases per [...]
Role of Membrane-Bound and Circulating Endoglin in Disease Endoglin (Eng), alias CD105, is a transmembrane glycoprotein whose mutations are responsible for a rare pathology called hereditary hemorragic telangectasia type 1. In addition, Eng seems to be implicated [...]
MicroRNAs and Stem Cells 3.0 MicroRNAs are involved in cellular processes such as differentiation, growth, and apoptosis. Stem cells have peculiar properties such as differentiation and selfrenewal, which can be strongly influenced by epigenetic changes. Notably, miRNAs [...]
Dental pulp stem cells (DPSCs) and tissue regeneration: mechanism mediated by direct, paracrine or autocrine effects A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine". Deadline for manuscript submissions: [...]
Cancer Genomics: Interpreting the Changing Landscape in Cancer Diagnosis and Treatment The expanding knowledge and comprehension of human genetics are transforming the path and direction of research and medical approaches to cancer diagnosis and treatment. Recent high-throughput [...]
Molecular and Cellular Mechanisms Underlying Probiotic Activity Basic and clinical studies have been providing increasing evidence that probiotic microorganisms can improve host health. Indeed, many scientific papers document that probiotics can balance the gut microbiota, reinforce [...]
