Università degli studi di Perugia
Last update: December 27, 2023
University Professors in Experimental Biology (BIO/13)
PROFESSOR
POSITION
AIBG
PO (Professore Ordinario / Full professor)
PA (Professore Associato / Associate Professor)
RTI (Ricercatore a Tempo Indeterminato / Assistant Professor)
RTD-A (Ricercatore a Tempo Determinato – Junior / Fixed-term Junior Assistant Professor)
RTD-B (Ricercatore a Tempo Determinato – Senior / Fixed-term Senior Assistant Professor)
Fellows in Experimental Biology (BIO/13)
FELLOW
POSITION
AIBG
Dominga Manfredelli – Dipartimento di Medicina e Chirurgia
D
A (Assegnista di Ricerca / Post-Doctoral Fellow)
D (Dottorando / PhD Student)
B (Borsista / Fellow)
T (Tutor)
Research
Research Group 1
Talesa Vincenzo Nicola
Cinzia Antognelli
Roberta Frosini (Technician)
Francesco Fabi (Technician)
Andrea Piazzoli (Technician)
Research Themes
- Biological role of glyoxalases and methylglyoxal-dependent glycative stress (advanced glycation end products accumulation) in human cancers.
- Biological role of glyoxalases and methylglyoxal-dependent glycative stress in rare diseases.
- Biological role of glyoxalases and methylglyoxal-dependent glycative stress in aging.
- Bioactive natural compounds as novel preventive agents against methylglyoxal-dependent glycative stress in human diseases.
Keywords: Glyoxalases, methylglyoxal, methylglyoxal-derived advanced glycation end products, glycative stress, RAGE, cancer, metabolism, bioactive natural compounds, rare diseases, aging.
Research Group 2
Maria Laura Belladonna
Ciriana Orabona (PA BIO/14 – Pharmacology)
Claudia Volpi (RTI BIO/14 – Pharmacology)
Maria Teresa Pallotta (PA BIO/14 – Pharmacology)
Giada Mondanelli (RTD-A BIO/14 – Pharmacology)
Eleonora Panfili
Chiara Suvieri
Sofia Rossini
Research Themes
- Plant-derived products for the therapy of chronic inflammatory bone diseases.
- Indoleamine 2,3-dioxygenase 1 (IDO1)-dependent tryptophan degradation in immune disorders and cancer.
- Biological role of indoleamine 2,3-dioxygenase 2 (IDO2) in non-small cell lung cancer.
- Identification of positive allosteric modulators (PAM) of the immunoregulatory enzyme IDO1.
Keywords: Plant-derived products, osteoclasts, bone homeostasis, tryptophan metabolism, IDO1, autoimmunity, cancer, IDO2, non-small cell lung cancer.
Research Group 3
Sabata Martino
Francesco Morena
Chiara Argentati
Ilaria Tortorella
Martina Bazzucchi
Research Themes
- Enzimi lisosomiali: sviluppo di saggi per la determinazione dell’attività enzimatica, studio della regolazione genica e espressione degli enizimi lisosomiali.
- Sviluppo di strategie di medicina traslazionale con cellule staminali / terapia genica per le malattie neurodegenerative genetiche (malattie da accumulo lisosomiale; malattia di Alzheimer)
- Generazione di modelli bioibridi di Cellule staminali / biomateriali per applicazioni di ingegneria tessutale.
- Delucidazione dei meccanismi molecolari di meccanotrasduzione/meccanosensing alla base della regolazione delle proprietà di automantenimento e multipotenzialità delle cellule staminali adulte.
Research Group 4
Letizia Mezzasoma
Francesco Fabi (Technician)
Research Themes
- Molecular mechanisms of inflammatory and immune responses to pathogen-associated molecular patterns in normal and cancerous cells.
- Biological role of de-regulated inflammasome activation in human diseases, aging and cancer.
- Biological effect of molecules and extracellular vesicles on inflammatory and immune cell phenotype.
Keywords: Inflammation, NLRP3 inflammasome, IL-1β, natriuretic pepides, cancer, immunemodulation, extracellular vesicles, aging.
Research Group 5
Rita Romani
Francesco Fabi (Technician)
Research Themes
- Human amniotic fluid stem cells and derived extracellular vesicles: characterization, immunoregulatory roles, applications in cell therapy.
Keywords: Stem cells, extracellular vesicles, immunoregulation.
Teaching
web page administrator: Cinzia Antognelli