Università degli Studi “Magna Graecia” di Catanzaro
Last Update: May 30, 2024
University Professors in Experimental Biology (BIO/13)
PROFESSOR
POSITION
AIBG
PO (Professore Ordinario / Full professor)
PA (Professore Associato / Associate Professor)
RTI (Ricercatore a Tempo Indeterminato / Assistant Professor)
RTD-A (Ricercatore a Tempo Determinato – Junior / Fixed-term Junior Assistant Professor)
RTD-B (Ricercatore a Tempo Determinato – Senior / Fixed-term Senior Assistant Professor)
Fellows in Experimental Biology (BIO/13)
FELLOW
POSITION
AIBG
Raffaella Gallo – Dipartimento di Medicina Sperimentale e Clinica
T
Emanuele Giorgio – Dipartimento di Medicina Sperimentale e Clinica
D
AIBG Member
Valentina Maggisano – Dipartimento Scienze della Salute
A
Lavinia Petriaggi – Dipartimento di Medicina Sperimentale e Clinica
D
AIBG Member
A (Assegnista di Ricerca / Post-Doctoral Fellow)
D (Dottorando / PhD Student)
B (Borsista / Fellow)
T (Tutor)
Research
Research Group 1
Flavia Biamonte
Anna Martina Battaglia
Emanuele Giorgio
Lavinia Petriaggi
Research Themes
- Analysis of ferroptosis sensitivity in ovarian cancer cells and cancer stem cells by using 2D and 3D experimental (Research Project PRIN 2022: Prot. 2022R85H27, Title: Ovarian cancer cells: from iron addiction to ferroptosis vulnerability. Principal Investigator, Flavia Biamonte).
- Pan-Cancer analysis of the cross-talk between tumor cells and tumor immune microenvironment: ferroptosis as immunogenic cell death.
- Analysis of exosome release as cell-cell communication in ovarian cancer cells.
- Biological mechanisms underlying Cadmium-mediated cytotoxicity in oral cancer.
- Isolation and characterization of cancer stem cells in oral cancer.
- Role of ferroptosis in the pathogenesis of psoriasis (Research Project PRIN PNRR BANDO 2022, Prot. P2022RBPHH Title: Multiple functions of CARD14 in keratinocyte differentiation, response to TLR-activation, ferroptosis and psoriasis pathogenesis. Co-Principal Investigator, Flavia Biamonte).
Keywords: cancer, ferroptosis, tumor microenvironment, stemness, cell-cell communication.
Research Group 2
Stefania Bulotta
Marilena Celano
Valentina Maggisano
Research Themes
- Development of molecules for reshaping tumor microenvironment in aggressive breast cancer: analysis of the effects of novel inhibitors of interleukin 20 receptor (Research Project PRIN 2022, Prot. 2022YHL52A, Co-Principal Investigator, Stefania Bulotta).
- Molecular and cellular mechanisms involved in the alteration of cellular differentiation and proliferation in normal and/or poorly differentiated epithelial cells.
- Molecular mechanisms and pathways involved in the regulation of tumor microenvironment (TME) in in vitro and in vivo experimental models.
- Biological effects of nutraceuticals focusing on olive oil polyphenols with antioxidant activity.
- Study on the biology of the endothelial nitric oxide synthase (eNOS) and its role in several physiological mechanisms
Keywords: epithelial cells, gene expression, tumor microenvironment (TME), interleukins, microRNA, bioactive polyphenols, antioxidant activity, eNOS, apoptosis, cellular migration and invasion.
Research Group 3
Giuseppe Fiume
Raffaella Gallo
Research Themes
- Exploring the Interplay between Tumor Growth Dynamics, Lipid Metabolism, and Inflammation in different tumor contexts: The Impact of FABP5 and NF-κB.
- Analysis of the activation and exhaustion mechanisms of immune cells, with particular focus on metabolic changes in different states.
- Development and characterization of next generation CAR-T (Chimeric Antigen Receptor T-cells).
Keywords: Cell metabolism; Immune cells activation; NF-kB; Inflammation; Tumor microenvironment; T-cells engineering.
Research Group 4
Eleonora Cianflone
Antonio Chiefalo
Loredana Pagano
Research Themes
- Assessing new cardiomyocyte formation in the adult mammalian heart in response to wear and tear and/or injury by resident tissue-specific Cardiac Stem/Progenitor Cells (CSCs).
- Assessing regenerative biology through clonogenicity, self-renewal, multipotency and particularly myogenic potential of CSCs in vitro and in vivo.
- Generation of human organoids from human iPSCs or CSCs as in vitro model of cardiac development and diseases.
- Assessing cardiac cell senescence and the mechanisms to revert the senescent phenotype of the heart during aging.
Keywords: Cardiac Stem Cells, Cardiac regeneration, cardiac cell senescence, cardiomyocytes, myogenic differentiation.
Teaching
BIO/13 Courses thaught by teachers of other Scientific-Disciplinary Sectors
web page administrator: Prof.ssa Stefania Bulotta