Alma Mater Studiorum – Università di Bologna
Last Update: August 25, 2023
University Professors in Experimental Biology (BIO/13)
PROFESSOR
POSITION
AIBG
PO (Professore Ordinario / Full professor)
PA (Professore Associato / Associate Professor)
RTI (Ricercatore a Tempo Indeterminato / Assistant Professor)
RTD-A (Ricercatore a Tempo Determinato – Junior / Fixed-term Junior Assistant Professor)
RTD-B (Ricercatore a Tempo Determinato – Senior / Fixed-term Senior Assistant Professor)
Fellows in Experimental Biology (BIO/13)
FELLOW
POSITION
AIBG
A (Assegnista di Ricerca / Post-Doctoral Fellow)
D (Dottorando / PhD Student)
B (Borsista / Fellow)
T (Tutor)
Research
Research Group 1
Pierluigi Strippoli
Maria Chiara Pelleri
Lorenza Vitale
Maria Caracausi
Allison Piovesan
Francesca Antonaros
Beatrice Vione
Research Themes
- Genomic and post-genomic analysis of human chromosome 21 in trisomy 21 (Down syndrome).
- Genotype-phenotype correlation in trisomy 21 to improve the understanding of the underlying biological and genetic mechanisms of Down syndrome and to identify targets for possible therapeutic applications.
- Structure and expression of the human genome and genes: computational biology and molecular genetic analysis.
Keywords: Human Genomics, Human Transcriptomics, Trisomy 21, Human chromosome 21, Down Syndrome Critical Region (DSCR), Genomics, Jérôme Lejeune.
Research Group 2
Provvidenza Maria Abruzzo
Cinzia Zucchini
Carmela Serpe
Paola De Sanctis (Technician)
Marina Marini (Consultant)
Alessandro Ghezzo (Consultant)
Alessandra Bolotta
Research Themes
Radical species as signals or as damaging agents: study of the molecular and cellular mechanisms involved in redox balance alterations.
- Role of reactive oxygen species in neurodevelopmental disorders (Autism Spectrum Disorder)
- Reactive oxygen species and iron homeostasis in cardiac functionality
- Effects of reactive oxygen and nitrogen species in tissue adaptations to physical exercise
Keywords: Oxidative stress, Reactive oxygen and nitrogen species, Autism Spectrum Disorder (ASD), Iron homeostasis, iPSC-derived cardiomyocytes, Physical exercise, NGS, Gene expression.
Research Group 3
Cinzia Zucchini
Marcella Martinelli (PA BIO/17 Histology)
Paola De Sanctis (Technician)
Research Themes
- Identification of new molecular markers of the invasive and metastatic phenotype of osteosarcoma and Ewing’s sarcoma and definition of their mechanisms of action. Identification of polymorphic variants of candidate genes, potentially involved in the development and progression of sarcomas.
Keywords: Osteosarcoma, Ewing Sarcoma, Gene expression profiles, Polimorfisms, Biomarkers, Invasiveness.
Research Group 4
Flavia Frabetti
Raffaella Casadei
Martina Fazzina
Research Themes
The group deals with functional genomics of complex human traits and has developed projects whose central objective is the analysis of the function of individual gene units and their mutual relationships within physiological and pathological cellular contexts, using approaches ranging from bioinformatics analysis, to cellular and molecular biology up to the use of model organisms such as zebrafish.
Updated research projects:
From the sequencing of the human genome, functional genomics has made important contributions in basic research and in the study of complex diseases. The group has developed skills and valuable collaborations in the following projects.
- Functional study of the CYYR1 multi-transcribed gene locus (21q21.3) in human cell lines and zebrafish model.
- Functional characterization of lncRNA (long non coding RNA) in Parkinson’s disease (PD): hypothesis of a neuroprotective role.
- Characterization of the physiological role played by TNPO3 (transportin3) in the regulation of myogenesis and possible implications of the gene alteration in LGMDD2 limb-girdle muscular dystrophy.
- Neutrophins in the stress response: molecular and ethological approaches in BDNF zebrafish null fish.
Keywords: Functional genomics, Transcriptomics, Zebrafish, cyyr1, TNPO3, lncRNA, Parkinson’s disease, BDNF.
Research Group 5
Silvia Canaider
Federica Facchin
Luca Pampanella
Giovannamaria Petrocelli
Carlo Ventura (PO BIO/11 Molecular Biology)
Research Themes
- Research into possible new modulators (natural stimuli and physical energies) of proliferation, differentiation and senescence of stem cells.
- Changes in the arrangement of the cytoskeleton to modulate the biology of human adult stem cells.
- Gender differences in human stem cells transcriptome.
Keywords: Stem Cells, Proliferation, Differentiation, Senescence, Physical energies, Natural molecules, Cytoskeleton.
Teaching
BIO/13 Courses thaught by teachers of other Scientific-Disciplinary Sectors
web page administrator: Allison Piovesan