The expanding knowledge and comprehension of human genetics are transforming the path and direction of research and medical approaches to cancer diagnosis and treatment.
Recent high-throughput sequencing technologies are gradually reshaping our understanding of cancer origin and complexity, providing more reliable information on tumor progression, metastases, and survival. Genome sequencing is now yielding insightful information about genetic mutations that trigger or contribute to cancer development and how cancer evolves in response to treatments.
In this way, cancer-genome profiling is now providing an important tool for the assessment of molecular cancer subtypes and the most appropriate therapeutic options for patients in routine clinical practice.
Deciphering the temporal series of events leading to cancer is essential for a comprehensive understanding of tumorigenesis, and for identifying the earliest markers in tumor development, ensuring faster diagnosis and treatment, as well as improving the capability to predict disease progression.
This Special Issue will cover key cancer genetics concepts and cutting-edge clinical applications.